EIF3e polyclonal antibody

CAT: 0384-BS7779-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS7779-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Component of the eukaryotic translation initiation factor 3 (eIF-3 complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC. The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD; may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
EIF3E; EIF3-P48; EIF3S6; INT6; eIF3-p46
Swiss Prot
P60228
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human eIF3e (NP_001559.1) .
Conjugation
Unconjugated
Applications
WB
Dilution
WB,1:500 - 1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
52kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Polyclonal Antibodies
Host or Source
Rabbit

Related Products

CatalogName
BS41230eIF3e Rabbit monoclonal antibody
BS47741-01EIF3e Recombinant Rabbit mAb
PPL80027-2aPDsRed1-N1-EIF3E (455-1792nt)
BS61567-01EIF3L polyclonal antibody
BS65385EIF3D polyclonal antibody
BS8655-01EIF3H polyclonal antibody
BS65306-01EIF3K polyclonal antibody
BS79561-01EIF4E polyclonal antibody
BS62373EIF3J polyclonal antibody
BS71841-01EIF3J polyclonal antibody

Alternative Products

CatalogName
MBS9126207-01EIF3E Polyclonal Antibody
TA346552EIF3E Rabbit Polyclonal Antibody
NBP3-30440Rabbit Polyclonal eIF3e Antibody
NBP1-52116Goat Polyclonal eIF3e Antibody
TA311210EIF3E Goat Polyclonal Antibody
E10G32221EIF3E (Center) Rabbit Polyclonal Antibody
MBS8125342-01Anti-EIF3E Antibody, Rabbit Polyclonal
HD106014-01Anti-Human EIF3E Polyclonal Antibody
MBS7138995Rabbit anti-Drosophila melanogaster (Fruit fly) EIF3E Polyclonal Antibody
MBS1496940-01Rabbit anti-human Eukaryotic translation initiation factor 3 subunit E polyclonal Antibody(EIF3E)

Popular Products