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BAG5 polyclonal antibody

CAT: 0384-BS7862-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS7862-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Bag-5 (Bcl-2-associated athanogene 5), also known as Bag family molecular chaperone regulator 5, is a member of the Bag family of proteins and contains four Bag domains. Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis. Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
BAG family molecular chaperone regulator 5; BAG-5; BAG5; BAG5_HUMAN; Bcl-2-associated athanogene 5; BCL2 associated athanogene 5; KIAA0873
Swiss Prot
Q9UL15
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human BAG5.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:2000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 51 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
BAG5 polyclonal antibody detects endogenous levels of BAG5 protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using BAG5 antibody.
Host or Source
Rabbit

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