PDCD10 polyclonal antibody

• Background:

  This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  CCM3; TFAR15; PDCD10

• Swiss Prot:

  Q9BUL8

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant full length Human PDCD10.

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC-P, IF/ICC

• Dilution:

  WB,1:500 - 1:1000|IHC-P,1:50 - 1:200|IF/ICC,1:50 - 1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  ~25 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  PDCD10 polyclonal antibody detects endogenous levels of PDCD10 protein.

• Applications Notes:

  Western blot analysis of various lysates, using PDCD10 pAb at 1:500 dilution.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4