LRP2 polyclonal antibody

CAT: 0384-BS71410-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS71410-01Size:50 µL
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Background
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Low-density lipoprotein receptor-related protein 2; LRP-2; Glycoprotein 330; gp330; Megalin
Swiss Prot
P98164
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human LRP2.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 522 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LRP2 polyclonal antibody detects endogenous levels of LRP2 protein.
Applications Notes
Western blot analysis of extracts of mouse lung cells, using LRP2 antibody.
Host or Source
Rabbit

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