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ANAPC5 polyclonal antibody

CAT: 0384-BS61681-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61681-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The anaphase-promoting complex (APC) is composed of more than ten subunits, including APC1, APC2, APC4, APC5, APC7, APC8, APC10 and APC11. The APC acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk) . APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC1, previously referred to as Tsg24 in mice, is the largest of the APC subunits and is encoded by a gene mapping to 2q12.1.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5; ANAPC5; APC5
Swiss Prot
Q9UJX4
Reactivity
Human
Immunogen
Synthetic peptide, corresponding Human ANAPC5.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 85 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ANAPC5 polyclonal antibody detects endogenous levels of ANAPC5 protein.
Applications Notes
Western blot (WB) analysis of ANAPC5 polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate (40ug) Lane2:HepG2 whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug) Lane4:A2780 whole cell lysate (40ug)
Host or Source
Rabbit

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