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TNNT2 polyclonal antibody

CAT: 0384-BS61520-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61520-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Troponin, working in conjunction with tropomyosin, functions as a molecular switch that regulates muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI) . In response to β-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Troponin T, cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT
Swiss Prot
P45379
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 149-193 of Human TNNT2.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Modification
Unmodification
Molecular Weight
~ 40 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TNNT2 polyclonal antibody detects endogenous levels of TNNT2 protein.
Applications Notes
Western blot (WB) analysis of TNNT2 polyclonal antibody at 1:500 dilution Lane1:The heart tissue lysate of Mouse (40ug) Lane2:The heart tissue lysate of Rat (40ug) Lane3:The fetal heart tissue lysate of Mouse (40ug)
Host or Source
Rabbit

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