POLG2 polyclonal antibody

CAT: 0384-BS61176-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS61176-01Size:50 µL
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Background
DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol γ2 (polymerase (DNA directed), gamma 2, accessory subunit), also known as mitochondrial DNA polymerase accessory subunit, POLB, HP55, PEOA4, POLGB, MTPOLB, POLG-BETA or POLG2, is a 485 amino acid subunit of mitochondrial DNA pol γ. DNA pol γ2 enhances DNA binding and promotes processive DNA synthesis. Defects in the gene encoding DNA pol γ2 are the cause of PEOA4 (progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
DNA polymerase subunit gamma-2; mitochondrial; p55; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta; POLG2
Swiss Prot
Q9UHN1
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human POLG2.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
POLG2 polyclonal antibody detects endogenous levels of POLG2 protein.
Applications Notes
Western blot (WB) analysis of POLG2 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:Hela whole cell lysate Lane3:H9C2 whole cell lysate Lane4:SP20 whole cell lysate
Host or Source
Rabbit

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