IL17D polyclonal antibody

• Background :

  Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. The proinflammatory cytokine Interleukin 17D (IL-17D), also known as IL-27, is the largest member of the IL-17 family of cytokines. It is produced by CD4+ T cells and is predominantly expressed in brain, lung, heart, adipose tissue, pancreas and skeletal muscle. IL-17D regulates the production of other cytokines in endothelial cells, including IL-6, IL-8 and GM-CSF. It may play a role in the activation of the endothelium, which is the site of attachment for migrating immune cells. In addition, IL-17D may play a role in the amplification of a local immune response.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  Interleukin-17D; IL-17D; Interleukin-27; IL-27; IL17D; IL27

• Swiss Prot :

  Q8TAD2

• Reactivity :

  Human

• Immunogen :

  A synthetic peptide corresponding to residues in Human IL17D.

• Conjugation :

  Unconjugated

• Applications :

  WB

• Dilution :

  WB: 1:500~1:1000

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 22 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  IL17D polyclonal antibody detects endogenous levels of IL17D protein.

• Applications Notes :

  Western blot (WB) analysis of IL17D polyclonal antibody at 1:500 dilution Line1:Hela whole cell lysate

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4