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ANXA7 polyclonal antibody

CAT: 0384-BS60862-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60862-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain, which binds to phospholipids in a Ca++-dependent manner, and a unique amino terminal region, which may confer binding specificity. The annexin family has been implicated as regulators of such diverse processes as ion-flux, endocytosis and exocytosis, and cellular adhesion. When overexpressed in A431 cells, Annexin VI causes a partial reversal of the transformed phenotype. It has been hypothesized that growth-dependent post-translational modifications of Annexins are required for proper sub-cellular localization Annexin VII, also referred to as synexin, is located at the plasma membrane in normal muscle tissue. However, in muscle samples from patients suffering from Duchenne’s muscular dystrophy, Annexin VII, along with Annexins IV and VI, is released into the cytoplasm and later, as the disease progresses, into the extracellular space. Two forms of Annexin XI, designated A and B, have been identified. Transfection of COS-7 cells with Annexin XI-A, but not Annexin XI-B, causes formation of Annexin XI-associated vesicles.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Annexin A7; Annexin VII; Annexin-7; Synexin; ANXA7; ANX7; SNX
Swiss Prot
P20073
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to residues in Human ANXA7.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 53 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ANXA7 polyclonal antibody detects endogenous levels of ANXA7 protein.
Applications Notes
Western blot (WB) analysis of ANXA7 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:sp2/0 whole cell lysate
Host or Source
Rabbit

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