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APOBR polyclonal antibody

CAT: 0384-BS60755-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60755-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ApoB48R (apolipoprotein B48 receptor), also known as apolipoprotein B-100 receptor, is a 1,088 amino acid protein that functions as a macrophage receptor by binding to apoB of dietary triglyceride-rich lipoproteins or to a similar apoB-like domain in hypertriglyceridemic very low density lipoprotein (HTG-VLDL) . ApoB48R may contribute necessary lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. Significantly elevated plasma triglyceride levels may cause apoB48R to be a factor in foam cell formation, endothelial dysfunction and atherothrombogenesis. ApoB48R also mediates the swift, high-affinity uptake of chylomicrons, HTG-VLDL and trypsinized VLDL lacking apoE in in vitro macrophages. Conserved in chimpanzee, dog, cow, mouse and rat, apoB48R is ubiquitously expressed in all tissues, except skeletal muscle, with high expression in lung and placenta, and low expression in brain and heart. ApoB48R is encoded by a gene that maps to human chromosome 16p11.2 and exists as three alternatively spliced isoforms.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor; Apolipoprotein B48 receptor; apoB-48R; APOBR; APOB48R
Swiss Prot
Q0VD83
Reactivity
Human, Rat
Immunogen
A synthetic peptide corresponding to residues in Human APOBR
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 115 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
APOBR polyclonal antibody detects endogenous levels of APOBR protein.
Applications Notes
Western blot (WB) analysis of APOBR polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:MCF-7 whole cell lysate Lane3:PC12 whole cell lysate
Host or Source
Rabbit