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C4A/C4B polyclonal antibody

CAT: 0384-BS60394-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60394-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The complementcomponent proteins C3, C4 and C5 are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactionsspecificto cells of hematopoieticlineage. These proteins belong to theα2-macroglobulin family, but retain distinctive featuresincluding an anaphylatoxin domain and a netrin (NTR) domain. The human C4 gene is polymorphic at two loci, C4A and C4B, mapping to chromosome 6p21.32. C4A expressesthe Rodgers (Rg) blood group Ag, while C4B expressesthe Chido (Ch) blood group Ag. C4 is expressed as a precursor that iscleaved into α, β and γ chains, all ofwhich are non-identicalcleavage products. Theαchain of C4may be cleaved to produce an acidicisotype, C4a, which reactswith amino groups, and a basicisotype, C4b, which reactswith hydroxyl groups. Deficiency in the C4 gene is associatedwith autoimmune or immune complex disorders, such assystemiclupus erythematosus.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Complement C4-A; Acidic complement C4 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain; C4A; CO4, CPAMD2
Swiss Prot
P0C0L4/P0C0L5
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human C4A.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 193 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
C4A/C4B polyclonal antibody detects endogenous levels of C4A and C4B protein.
Applications Notes
Western blot (WB) analysis of C4A/C4B polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
Host or Source
Rabbit

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