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SLC6A8 polyclonal antibody

CAT: 0384-BS5934-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5934-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SLC6A8 (solute carrier family 6 member 8), also known as CT1 (creatine transporter 1), CRT or CRTR, is a 635 amino acid multi-pass plasma membrane protein that belongs to the sodium/neurotransporter (SNF) family. Expressed in a variety of tissues including kidney, skeletal muscle, heart, brain, prostate, testis and colon, SLC6A8 functions to transport creatine into and out of cells, specifically those found in brain and muscle tissue. Creatine, an organic acid, occurs naturally and is essential for supplying the energy needed for proper muscle and nerve function. Defects in the gene encoding SLC6A8 lead to cerebral creatine deficiency and are the cause of X-linked creatine deficiency syndrome, a rare disorder characterized by facial anomalies, seizures and mental retardation. Multiple isoforms of SLC6A8 exist due to alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8
Swiss Prot
P48029
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 590-635 of Human SLC6A8.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 70 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SLC6A8 polyclonal antibody detects endogenous levels of SLC6A8 protein.
Applications Notes
Western blot (WB) analysis of SLC6A8 polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate
Host or Source
Rabbit

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