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MAD2L1BP polyclonal antibody

CAT: 0384-BS5788-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5788-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAD2L1BP (MAD2L1 binding protein), also known as CMT2, is a 274 amino acid protein that localizes to the nucleoplasm during early mitosis and to the spindle from metaphase through anaphase. Functioning as a component of the spindle checkpoint (which delays the onset of anaphase until kineotochore attachment is complete), MAD2L1BP is thought to coordinate cell cycle events in late mitosis, possibly binding to MAD2, thereby silencing the spindle checkpoint and allowing mitosis to proceed. MAD2L1BP is expressed as multiple alternative spliced isforms that, upon DNA damage, may be phosphorylated by ATM or ATR. The gene encoding MAD2L1BP maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
MAD2L1-binding protein; MAD2L1 binding protein; Caught by MAD2 protein; CMT2; KIAA0110
Swiss Prot
Q15013
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 40-85 of Human MAD2L1BP.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 34 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MAD2L1BP polyclonal antibody detects endogenous levels of MAD2L1-binding protein protein.
Applications Notes
Western blot (WB) analysis of MAD2L1BP polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate
Host or Source
Rabbit

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