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FSHR polyclonal antibody

CAT: 0384-BS5724-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5724-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG) . In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor; LGR1
Swiss Prot
P23945
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 330-375 of Human FSHR.
Conjugation
Unconjugated
Applications
WB IHC ICC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 78 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
FSHR polyclonal antibody detects endogenous levels of FSHR protein.
Applications Notes
Western blot (WB) analysis of FSHR pAb at 1:500 dilution Lane1:A2780 whole cell lysate (20ug) Lane2:SK-OVCAR3 whole cell lysate (20ug) Lane3:The Testis tissue lysate of Mouse (40ug) Lane4:The Ovary tissue lysate of Rat (40ug)
Host or Source
Rabbit

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