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CYP4F2 polyclonal antibody

CAT: 0384-BS5690-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5690-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes omega-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4 as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA) . CYP4F2 participates in the omega-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Leukotriene-B (4) omega-hydroxylase 1; CYPIVF2; Cytochrome P450 4F2; Cytochrome P450-LTB-omega; Leukotriene-B (4) 20-monooxygenase 1
Swiss Prot
P78329
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 76-121 of Human CYP4F2.
Conjugation
Unconjugated
Applications
WB IHC ICC IP
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CYP4F2 polyclonal antibody detects endogenous levels of CYP4F2 protein.
Applications Notes
Western blot (WB) analysis of CYP4F2 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:NIH-3T3 cell lysate Lane3:PC12 cell lysate
Host or Source
Rabbit

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