CD1E polyclonal antibody

• Background:

  CD1E, also known as R2 or CD1A, is a 322 amino acid single-pass type I membrane protein that localizes to the lumen of the endoplasmic reticulum, as well as to the golgi apparatus, and contains one Ig-like domain. Expressed in a variety of tissues and on cortical thymocytes, dendritic cells and Langerhans cells, CD1E exists as a heterodimer with β-2-Microglobulin and is necessary for the presentation of glycolipid antigens on the cell surface. CD1E is subject to post-translational mono-ubiquitination and may also be proteolytically cleaved in endosomes to yield a soluble protein. CD1E is present on the surface of some T-cell leukemias, suggesting a possible role in tumorigenesis.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  T-cell surface glycoprotein CD1e, membrane-associated; hCD1e; R2G1; CD1e; T-cell surface glycoprotein CD1e, soluble; sCD1e

• Swiss Prot:

  P15812

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide, corresponding to amino acids 258-303 of Human CD1E.

• Conjugation:

  Unconjugated

• Applications:

  WB ICC

• Dilution:

  WB: 1:500~1:1000 ICC: 1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 44 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD1E polyclonal antibody detects endogenous levels of CD1E protein.

• Applications Notes:

  Western blot (WB) analysis of CD1E polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4