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BRCA2 (N60) polyclonal antibody

CAT: 0384-BS2864-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS2864-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25% of sporadic breast tumors, which indicates that BRCA 2 might be a tumor suppressor gene. BRCA 2 confers only a low ovarian cancer risk. Reportedly, in MCF-10F (normal breast epithelial cell line) and MCF-7 (breast cancer cell line) cells the expression of BRCA 2 RNA lowers in G0 and early G1 phases then gets up-regulated at the G1 / S phase junction.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Fanconi anemia group D1 protein; Breast cancer type 2 susceptibility protein; BRCA2; FACD; FANCD1
Swiss Prot
P51587
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 60-100 of Human BRCA2.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 384 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
BRCA2 (N60) polyclonal antibody detects endogenous levels of BRCA2 protein.
Host or Source
Rabbit

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