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SDHA (R600) polyclonal antibody

CAT: 0384-BS2847-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS2847-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Succinate dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial; Flavoprotein subunit of complex II; Fp; SDHA; SDH2; SDHF
Swiss Prot
P31040
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 560-610 of Human SDHA.
Conjugation
Unconjugated
Related Pathways
Warburg Effect, Insulin &Glucose Signaling, AMPK Signaling Pathway
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 72 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SDHA (R600) polyclonal antibody detects endogenous levels of SDHA protein.
Applications Notes
Western blot (WB) analysis of SDHA (R600) pAb at 1:2000 dilution Lane1:The Heart tissue lysate of Rat (20ug) Lane2:The Testis tissue lysate of Mouse (40ug) Lane3:HEK293T whole cell lysate (40ug) Lane4:SGC7901 whole cell lysate (40ug) Lane5:HepG2 whole cell lysate (40ug)
Host or Source
Rabbit

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