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ADNP polyclonal antibody

CAT: 0384-BS2362-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS2362-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Activity-dependent neuroprotector (ADNP), also designated activity-dependent neuroprotective protein, is a nuclear protein that functions as a putative transcription factor and may participate in normal growth and cancer proliferation. ADNP is a highly conserved vasoactive intestinal peptide (VIP) responsive gene that is expressed profusely in the brain (primarily cerebellum and cortex regions) and is crucial for brain formation and embryonic development. ADNP is also highly expressed in kidney, placenta, heart, skeletal muscle, breast, and colon cancer tissues. Studies indicate that neuroprotection by subpicomolar PACAP38 might be mediated partially by expression of ADNP. A correlation between brain injuries and elevated ADNP levels indicates a potential involvement of ADNP in an endogenous compensatory mechanism.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Activity-dependent neuroprotector homeobox protein; Activity-dependent neuroprotective protein; ADNP; ADNP1; KIAA0784
Swiss Prot
Q9H2P0
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding Human ADNP.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 123 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ADNP polyclonal antibody detects endogenous levels of ADNP protein.
Applications Notes
Western blot (WB) analysis of ADNP polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:HCT116 whole cell lysate (40ug) Lane3:The Kidney tissue lysate of Rat (40ug) Lane4:The Embryo tissue lysate of Mouse (40ug)
Host or Source
Rabbit

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