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Cables1 (K588) polyclonal antibody

CAT: 0384-BS2218-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS2218-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cables, a 568 amino-acid protein, links Abl to cyclin-dependent kinase 5 (Cdk5) . Cables bound to Cdk5 functions as a substrate for phosphorylation by the Cdk5/p35 kinase. Cables contains an area of weak homology to cyclin A and cyclin C. In addition to its C-terminal Cdk5 binding domain, Cables also has six potential SH3 binding motifs (PXXP) clustered around the amino terminus, two of which are similar to motifs known to bind the Abl SH3 domain. Cables forms a trimolecular complexwith Cdk5 and Abl in vivo. All three proteins colocalize within cortical axons, particularly in their growth cones. Cables and Abl may function as adaptor or scaffolding proteins to bind to Cdk5 and control its subcellular location in the neuron.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
CDK5 and ABL1 enzyme substrate 1; Interactor with CDK3 1; Ik3-1; CABLES1; CABLES
Swiss Prot
Q8TDN4
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 550-600 of Human Cables1.
Conjugation
Unconjugated
Applications
IHC IF
Dilution
IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 67 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cables1 (K588) polyclonal antibody detects endogenous levels of Cables1 protein.
Host or Source
Rabbit

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