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C1S (K583) polyclonal antibody

CAT: 0384-BS3839-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS3839-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C1s proenzyme is a glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa) . The Ca dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
C1 esterase; Complement C1s subcomponent; Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain; Complement component 1 s subcomponent
Swiss Prot
P09871
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 551-600 of Human C1S.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 90 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
C1s (K583) polyclonal antibody detects endogenous levels of C1s protein.
Applications Notes
Western blot (WB) analysis of C1s (K583) pAb at 1:500 dilution Lane1:AML-12 whole cell lysate (40ug) Lane2:PC12 whole cell lysate (40ug) Lane3:HepG2 whole cell lysate (40ug) Lane4:SK-OVCAR3 whole cell lysate (40ug)
Host or Source
Rabbit

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