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COXII polyclonal antibody

CAT: 0384-BS1653-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1653-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general “housekeeping” functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cytochrome c oxidase polypeptide 2; Cytochrome c oxidase subunit 2; Cytochrome c oxidase subunit II; Cytochrome oxidase subunit 2; mt-Co2; Co2; COII; COX2; Cox2; COXII
Swiss Prot
Q7JCZ1
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to amino acids 49-63 of Mouse COXII.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 26 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
COXII polyclonal antibody detects endogenous levels of COXII protein.
Applications Notes
Western blot (WB) analysis of COXII polyclonal antibody at 1:1000 dilution Lane1:HepG-2 whole cell lysate (50μg) Lane2:The muscle tissue lysate of Mouse (33μg)
Host or Source
Rabbit

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