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CD40 (Q259) polyclonal antibody

CAT: 0384-BS1458-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1458-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A receptor ligand pair central to the transmission of this signal is CD40, expressed on the surface of B cells, together with CD40L, expressed on activated T cells. In the presence of such stimulus, IL-4 and IL-13 are capable of triggering immunoglobulin class switching and secretion of IgE. B cells are sensitive to these cytokines only subsequent to CD40/CD40L-driven DNA synthesis. A downstream mediator of the CD40 signaling pathway, designated CRAF, is a member of an expanding family of proteins that contain a conserved cysteine- and histidine-rich RING finger motif. Other members of the family include TRAF1 and TRAF2. The latter proteins have been shown to regulate TNF-R2 as well as CD40 signaling through activation of the NFκB family of transcription factors.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD40; CD40; TNFRSF5
Swiss Prot
P25942
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 230-280 of Human CD40.
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas, Immune checkpoint signaling in the Tumor Microenvironment
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 30 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD40 (Q259) polyclonal antibody detects endogenous levels of CD40 protein.
Applications Notes
Western blot (WB) analysis of CD40 (Q259) pAb at 1:500 dilution Lane1:C6 whole cell lysate (40ug) Lane2:AML-12 whole cell lysate (40ug) Lane3:HepG2 whole cell lysate (40ug) Lane4:U-87MG whole cell lysate (40ug)
Host or Source
Rabbit

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