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CD40 monoclonal antibody

CAT: 0384-MB66945-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66945-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD40, also known as tumor necrosis factor receptor superfamily member 5 (TNFRSF5), is a type I transmembrane protein expressed on the surface of B cells and professional antigen-presenting cells of the immune system, as well as on several non-hematopoietic cell types and cancers . CD40 interacts with CD40 ligand (CD40L/TNFSF5), which is expressed primarily on activated T cells but has also been reported on blood platelets, mast cells, basophils, NK cells, and B cells . Upon engagement with CD40L, CD40 signals through TNF receptor associated factors and MAP kinase signaling pathways, resulting in a wide variety of immune and inflammatory responses, including dendritic cell activation and cross-presentation, T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation . The CD40/CD40L axis is essential for the initiation and progression of cellular and humoral adaptive immunity, and is an important area of interest in the study of tumor immunology, neurodegenerative diseases, vascular diseases, and inflammatory disorders.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.
Product Name Alternative
TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD40
Swiss Prot
P25942
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD40. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Modification
Unmodification
Molecular Weight
~ 31 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CD40 protein.
Applications Notes
Western blot analysis of CD40 expression in HL60 (A) whole cell lysates.
Host or Source
Mouse

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