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Myc (K52) polyclonal antibody

CAT: 0384-BS1244-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1244-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64; MYC; BHLHE39
Swiss Prot
P01106
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 21-70 of Human Myc.
Conjugation
Unconjugated
Related Pathways
Warburg Effect, Signaling Pathways Activating p38 MAP KinaseCell Cycle Control G1 S Checkpoint, Glutamine Metabolism
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 49, 57, 65 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Myc (K52) polyclonal antibody detects endogenous levels of proto-oncogene c-Myc protein.
Host or Source
Rabbit

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