CD11B (E1) polyclonal antibody

• Background:

  Integrin αM, also designated complement component receptor-3 α, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin αM combines with the Integrin β2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3) . Integrin αM/β2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b; ITGAM; CD11B; CR3A; Integrin αM; CR-3α; CR3α

• Swiss Prot:

  P11215

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant full length Human CD11B (339aa-629aa) .

• Conjugation:

  Unconjugated

• Related Pathways:

  Neuronal and Glial Cell Marker Atlas, Tumor-Infiltrating Immune Cell Marker Guide

• Applications:

  WB

• Dilution:

  WB: 1:500~1:1000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 170 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD11B (E1) polyclonal antibody detects endogenous levels of CD11B protein.

• Applications Notes:

  Western blot (WB) analysis of CD11B (E1) polyclonal antibody at 1:500 dilution Lane1:THP-1 cell lysate Lane2:Raw264.7 cell lysate Lane3:PC12 cell lysate

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4