Sox2 polyclonal antibody

CAT: 0384-AP0014-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-AP0014-01Size:50 µL
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Background
SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX 2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Transcription factor SOX-2
Swiss Prot
P48431
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 100-150 of Human Sox2.
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas, ESC Pluripotency and Differentiation Signaling Pathway
Applications
WB
Dilution
WB: 1:500~1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 34, 43 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Sox2 polyclonal antibody detects endogenous levels of sox2 protein.
Applications Notes
Western blot (WB) analysis of Sox2 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
Host or Source
Rabbit

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