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P2RY2 polyclonal antibody

CAT: 0384-BS7856-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS7856-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nucleotides are emerging as important extracellular signaling molecules that mediate several effects, such as proliferation, differentiation, chemotaxis and cytokine release. The P2 receptor family is activated by the binding of nucleotides and is divided into two subfamilies, P2X and P2Y. The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The P2Y receptor family are G protein-coupled receptors which mediate the effects of extracellular nucleotides, primarily through the activation of phospholipase C. To some extent, the P2Y receptors can also activate potassium channels or, alternatively, inhibit adenylate cyclase and N-type calcium channels in response to extracellular nucleotides. The P2Y receptors are differentially expressed in several tissue types, such as heart, lung and brain. However, all P2Y receptors are expressed in leukocytes, which suggests a role for the P2Y receptor family in the activation of leukocytes and platelets in response to inflammation or vascular damage.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ATP receptor; HP2U; Human P2U nucleotide receptor mRNA complete cds; MGC20088; MGC40010; P2RU1; P2RY2; P2RY2_HUMAN; P2U; P2U nucleotide receptor; P2U purinoceptor 1; P2U receptor 1; P2U1; P2UR; P2Y purinoceptor 2; P2Y2; P2Y2R; Purinergic receptor; Purinergic receptor P2Y G protein coupled 2; Purinergic receptor P2Y2; Purinoceptor P2Y2
Swiss Prot
P41231
Reactivity
Human, Mouse
Immunogen
Recombinant full length Human P2RY2.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:500~1:2000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P2RY2 polyclonal antibody detects endogenous levels of P2RY2 protein.
Applications Notes
WesternBlot (WB) analysis of P2RY2 polyclonal antibody
Host or Source
Rabbit

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