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Integrin β1 (Y783) polyclonal antibody

CAT: 0384-BS1444-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1444-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD29; ITGB1; FNRB; MDF2; MSK12
Swiss Prot
P05556
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 741-790 of Human Integrin β1.
Conjugation
Unconjugated
Related Pathways
Regulation of Actin Dynamics, Tumor Angiogenesis, Contribution of ECM and Cytoskeletal Factors to EMT
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 115 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ITGB1 (Y783) polyclonal antibody detects endogenous levels of ITGB1 protein.
Applications Notes
Western blot (WB) analysis of ITGB1 pAb at 1:500 dilution Lane1:U-87MG whole cell lysate (40ug) Lane2:A375 whole cell lysate (40ug) Lane3:The Skin tissue lysate of Rat (40ug) Lane4:CT26 whole cell lysate (40ug)
Host or Source
Rabbit

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