Mannose Binding Protein polyclonal antibody

• Background:

  Mannose-binding lectin protein C (MBL-C), also known as mannose-binding protein C; mannose-binding lectin 2, soluble (opsonic defect) ; mannan-binding lectin; mannan-binding protein; and soluble mannose-binding lectin, initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL-C is a key component in immune response due to its ability to directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. It binds to sugars on the surface of bacterial, fungal and parasitic cells through C-terminal, Ca2+-dependent carbohydrate-recognition domains. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, two types of MBL-associated serine proteases (MASP-1 and MASP-2) and a truncated form of MASP-2, designated small MBL-associated protein (sMAP) or MAp19, complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

• Product Name Alternative:

  COLEC 1; COLEC1; Collectin-1; HSMBPC; Mannan binding lectin; Mannan binding protein; Mannan-binding protein; Mannose binding lectin (protein C) 2 soluble; Mannose binding lectin (protein C) 2, soluble (opsonic defect) ; Mannose binding lectin (protein C) 2, soluble; Mannose binding lectin 2 soluble; Mannose binding lectin 2, soluble (opsonic defect) ; Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor; Mannose-binding lectin; Mannose-binding protein C; MBL 2; MBL; MBL2; MBL2_HUMAN; MBL2D; MBP 1; MBP; MBP C; MBP-C; MBP1; MBPB; MBPC; MGC116832; MGC116833; Opsonic defect; protein C; Soluble mannose binding lectin

• Swiss Prot:

  P11226

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Synthetic peptide, corresponding to Human Mannose Binding Protein.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB:1:500~1:1000

• Purity:

  The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 26 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Mannose Binding Protein polyclonal antibody detects endogenous levels of Mannose Binding protein.

• Applications Notes:

  Western blot (WB) analysis of Mannose Binding Protein polyclonal antibody at 1:500 dilution LaneA:HepG2 whole cell lysate LaneB:Aml-12 whole cell lysate LaneC:PC12 whole cell lysate LaneD:L02 whole cell lysate

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4