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SIX1 polyclonal antibody

CAT: 0384-BS62393-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS62393-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Sx4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Homeobox protein SIX1; Sine oculis homeobox homolog 1; SIX1
Swiss Prot
Q15475
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human SIX1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 43 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SIX1 polyclonal antibody detects endogenous levels of SIX1 protein.
Applications Notes
Western blot (WB) analysis of SIX1 polyclonal antibody at 1:500 dilution LaneA:PC12 whole cell lysate LaneB:MEF whole cell lysate LaneC:COS-7 whole cell lysate
Host or Source
Rabbit

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