TAB1 polyclonal antibody

CAT: 0384-BS62266-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS62266-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1; TAB1; MAP3K7IP1
Swiss Prot
Q15750
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to Human TAB1.
Conjugation
Unconjugated
Related Pathways
NF-kB Signaling
Applications
WB IHC
Dilution
WB:1:500~1:1000 IHC:1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TAB1 polyclonal antibody detects endogenous levels of TAB1 protein.
Applications Notes
Western blot (WB) analysis of TAB1 polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:HEK293T whole cell lysate
Host or Source
Rabbit

Related Products

CatalogName
BS64578-01TAB1 (Phospho-S438) polyclonal antibody
MB0107-01TAB1 monoclonal antibody
BS41004-01TAB1 Rabbit monoclonal antibody
PPL00021-2aPcDNA3-HA-TAB1
BS47578TAB1 Recombinant Rabbit mAb
PPL00021-3aPPLK/GFP+Puro-TAB1 shRNA-1
BS77853-01TAB3 polyclonal antibody
BS79287-01TAB2 polyclonal antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody
BS41065TAB3 Rabbit monoclonal antibody

Alternative Products

CatalogName
APR06357GPolyclonal TAB1 Antibody
MBS2542933-01TAB1 Polyclonal Antibody
TA306187TAB1 Rabbit Polyclonal Antibody
NBP1-76595Rabbit Polyclonal TAB1 Antibody
PHH18301Anti-TAB1 Polyclonal Antibody

Popular Products