DUSP27 Polyclonal Antibody

• Background:

  Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members, including MAPK/ERK, SAPK/JNK and p38. DUSP27 (dual specificity phosphatase 27), also known as FMDSP or DUPD1 (dual specificity phosphatase and pro isomerase domain containing 1), is a 220 amino acid cytoplasmic protein that belongs to the protein-tyrosine phosphatase family. Expressed in skeletal muscle, liver and adipose tissue, DUSP27 may play a role in energy metabolism. The gene encoding DUSP27 is referred to as DUPD1 and maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.

• Structure Composition:

  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

• Product Name Alternative:

  Atypical dual specific protein phosphatase; Dual specificity phosphatase 27; Dual specificity phosphatase and pro isomerase domain containing 1; Dual specificity phosphatase DUPD1; dupd1; DUPD1_HUMAN; DUSP27; OTTHUMP00000019871.

• Swiss Prot:

  Q68J44

• Reactivity:

  Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep

• Immunogen:

  KLH conjugated synthetic peptide derived from human DUSP27:21-120/220

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB=1:500-2000

• Purity:

  Affinity purified by Protein A

• Modification:

  Unmodification

• Molecular Weight:

  27 kD

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  DUSP27 Polyclonal Antibody detects endogenous levels of DUSP27 protein.

• Applications Notes:

  Primary: Anti- DUSP27 at 1/1000 dilution

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4