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IkB-α (S36) polyclonal antibody

CAT: 0384-BS3601-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS3601-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins. Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB. IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
Swiss Prot
P25963
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to Human IkB-α.
Conjugation
Unconjugated
Related Pathways
Regulation of Apoptosis, Death Receptor Signaling, MAPK Erk in Growth and Differentiation Pathway (, Inhibition of Apoptosis, NF-kB Signaling, Phospholipase Signaling, T cell receptor signaling, Toll-like Receptor signaling
Applications
WB IF
Dilution
WB: 1:1000~1:2000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95%
Modification
Unmodification
Molecular Weight
~ 39 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IkB-α (S36) polyclonal antibody detects endogenous levels of IkB-α protein.
Applications Notes
Western blot (WB) analysis of IkB-α (S36) polyclonal antibody at 1:1000 dilution Lane1:MEF whole cell lysate (40ug) Lane2:MCF-7 whole cell lysate (40ug) Lane3:HepG2 whole cell lysate (40ug)
Host or Source
Rabbit

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