BMAL2 polyclonal antibody

• Background:

  BMAL2, also known as ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2), MOP9, CLIF or PASD9, is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  Aryl hydrocarbon receptor nuclear translocator-like protein 2; Basic-helix-loop-helix-PAS protein MOP9; Brain and muscle ARNT-like 2; CYCLE-like factor; CLIF; Class E basic helix-loop-helix protein 6; bHLHe6; Member of PAS protein 9; PAS domain-containing protein 9

• Swiss Prot:

  Q8WYA1

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide, corresponding to Human BMAL2.

• Conjugation:

  Unconjugated

• Applications:

  WB IHC

• Dilution:

  WB: 1:1000~1:2000 IHC: 1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 70 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  BMAL2 polyclonal antibody detects endogenous levels of BMAL2 protein.

• Applications Notes:

  Western blot (WB) analysis of BMAL2 polyclonal antibody at 1:2000 dilution Lane1:A549 whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4