ATRIP polyclonal antibody

• Background:

  The product of the ATRIP gene is an essential component of the DNA damage checkpoint, and binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  ATR-interacting protein; ATM and Rad3-related-interacting protein; ATRIP; AGS1

• Swiss Prot:

  Q8WXE1

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide, corresponding to Human ATRIP.

• Conjugation:

  Unconjugated

• Applications:

  WB IHC IF ICC

• Dilution:

  WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 ICC 1:50 - 1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 95 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  ATRIP polyclonal antibody detects endogenous levels of ATRIP protein.

• Applications Notes:

  Western blot analysis of ATRIP expression in Jurkat (A) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4