Centrin-2 polyclonal antibody

CAT: 0384-BS67314-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS67314-01Size:50 µL
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Background
Centrins are small conserved microtubule nucleating proteins localized to centrosomes, also known as microtubule organizing centers (MTOC), in eukaryotic cells. Centrin-1 is associated with cells that have cilia and flagella, whereas centrin-2 and -3 are ubiquitously expressed and important in centrosome duplication during cell division, as well as the structure and function of the MTOC . Human centrin-2 has also been shown to localize to nuclear pores and to have a role in regulation of mRNA export . The yeast ortholog of centrin-2, CDC31, plays a part in control of protein degradation and sensitivity to DNA damage .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
CALT; CEN2; Centrin-2; Caltractin isoform 1
Swiss Prot
P41208
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length protein of human Centrin-2
Conjugation
Unconjugated
Applications
WB, IF/ICC
Dilution
WB (1/500 - 1/2000), IF/ICC (1/50 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 20 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Centrin-2 protein.
Applications Notes
Western blot analysis of Centrin-2 expression in HT29 (A), MCF7 (B), mouse spleen (C) whole cell lysates.
Host or Source
Rabbit

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