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CGK 2 polyclonal antibody

CAT: 0384-BS67256-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67256-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Crucial regulator of intestinal secretion and bone growth (By similarity) . Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity) . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity) . Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity) .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
PRKGR2; cGMP-dependent protein kinase 2; cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII
Swiss Prot
Q13237
Reactivity
Human, Mouse
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human cGK 2. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/100 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 217% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 13 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of cGK 2 protein.
Applications Notes
Western blot analysis of cGK 2 expression in A549 (A), NIH3T3 (B), HEK293T (C) whole cell lysates.
Host or Source
Rabbit

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