PTEN (S385) polyclonal antibody

CAT: 0384-AP0609-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-AP0609-01Size:50 µL
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Background
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns (3,4,5) P3 > PtdIns (3,4) P2 > PtdIns3P > Ins (1,3,4,5) P4.The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression andcell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog
Swiss Prot
P60484
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human PTEN.
Conjugation
Unconjugated
Related Pathways
Phosphoinosotode Signaling, PI3K AKT signaling, Translational Contral elF4 and p70 S6 Kinase, Regulation of Microtubule Dynamics, Inhibition of Apoptosis, Insulin &Glucose Signaling, MTOR signaling
Applications
WB
Dilution
WB: 1:1000~1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 52 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PTEN (S385) polyclonal antibody detects endogenous levels of PTEN protein.
Applications Notes
Western blot (WB) analysis of PTEN (S385) polyclonal antibody at 1:1000 dilution Lane1:A549 whole cell lysate (30ug) Lane2:HepG2 whole cell lysate (30ug) Lane3:HEK293T whole cell lysate (30ug) Lane4:PC12 whole cell lysate (30ug) Lane5:BV2 whole cell lysate (30ug)
Host or Source
Rabbit

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