LAMP2a polyclonal antibody

CAT: 0384-BS90788-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS90788-01Size:50 µL
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Background
Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107A) and LAMP-2 (also designated CD107B) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans Golgi network and are transported intracellularly via a pathway that is distinct from the clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Lysosome-associated membrane glycoprotein 2; LAMP-2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B; LGP-96; CD107b; LAMP2
Swiss Prot
P13473
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human LAMP2a.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 38 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LAMP2a polyclonal antibody detects endogenous levels of LAMP2a protein.
Applications Notes
Western blot (WB) analysis of LAMP2a polyclonal antibody at 1:500 dilution LaneA:A375 cell membrane lysate (40ug) LaneB:DLD cell membrane lysate (40ug) LaneC:The Lung tissue lysate of Mouse (40ug) LaneD:The Liver tissue lysate of Mouse (40ug) LaneE:The Lung tissue lysate of Rat (40ug) LaneF:The Liver tissue lysate of Rat (40ug)
Host or Source
Rabbit

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