CD321 polyclonal antibody

• Background:

  Junctional Adhesion Molecule-A/F11 Receptor (JAM-A/F11R) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. JAM-A regulates multiple cellular processes, including tight junction assembly, epithelial-mesenchymal transition (EMT), leukocyte migration, virus binding, platelet activation, and angiogenesis. Aberrant expression of JAM-A is correlated with poor patient prognosis in several human cancers. In a mouse model of atherosclerosis, an antagonistic peptide that inhibits JAM-A-expressing platelets from interacting with inflamed endothelial cells reduces atherosclerotic plaque formation.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD_antigen: CD321; F11R; JAM1; JCAM; UNQ264/PRO301

• Swiss Prot:

  Q9Y624

• Reactivity:

  Human

• Immunogen:

  Recombinant protein of human CD321.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:2000~1:5000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 38 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD321 polyclonal antibody detects endogenous levels of CD321 protein.

• Applications Notes:

  Western blot (WB) analysis of CD321 polyclonal antibody at 1:2000 dilution Lane1:HEK293T whole cell lysate (30ug) Lane2:A549 whole cell lysate (30ug) Lane3:HepG2 whole cell lysate (30ug)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4