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CXCR-3 polyclonal antibody

CAT: 0384-BS6993-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS6993-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The CXC or a chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemo-attractants for neutrophils. The CXC family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 or SDF-1. SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes but not neutrophils. Receptors for the CXC family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB, CXCR-3 and fusin (variously referred to as LESTR or CXCR-4) . CXCR-3, also known as IP-10/Mig receptor, mediates Ca++ mobilization and chemotaxis in response to the CXC chemo-kines IP-10 and Mig. CXCR-3 is highly expressed in IL-2-activated T lymphocytes, but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD183; GPR9; CXCR3
Swiss Prot
P49682
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to Human CXCR-3.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB 1:500 - 1:1000 IHC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 44 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CXCR-3 polyclonal antibody detects endogenous levels of CXCR-3 protein.
Applications Notes
Western blot (WB) analysis of CXCR-3 polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate (40ug) LaneB:Hela whole cell lysate (40ug) LaneC:The Heart tissue lysate of Mouse (40ug) LaneD:The Kidney tissue lysate of Mouse (40ug)
Host or Source
Rabbit

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