TRAF3 polyclonal antibody

• Background:

  TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively) . Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2. A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40. The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a “TRAF-C” domain that is necessary and sufficient for CD40 binding and homodimerization.

• Structure Composition:

  0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Product Name Alternative:

  CD40 receptor-associated factor 1; CRAF1; CD40-binding protein; CD40BP; LMP1-associated protein; LAP1; CAP-1; TRAF3; 7187; TRAF3; 601896; Q13114; CAP-1; CD40bp; CRAF1; LAP1

• Swiss Prot:

  Q13114

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  KLH conjugated synthetic peptide derived from human TRAF3: 101-200/568

• Conjugation:

  Unconjugated

• Related Pathways:

  NF-kB Signaling, STING Signaling, Toll-like Receptor signaling, Death Receptor Signaling

• Applications:

  WB ELISA IHC IF

• Dilution:

  WB: 1:500-1:2000 ELISA: 1:5000-1:10000 IHC: 1:100-1:500 IF: 1:100-1:500

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 62 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  TRAF3 polyclonal antibody detects endogenous levels of TRAF3 protein.

• Applications Notes:

  Sample:Spleen (Mouse) Lysate at 40 ug Primary: Anti-TRAF3 at 1/300 dilution

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4