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CYP3A4 polyclonal antibody

CAT: 0384-BS90368-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS90368-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CYP3A, the most abundant p450 enzyme in human liver, is responsible for the metabolism of more than 50% of the clinical test & lt; RTI ID = 0.0 & gt; (cYP3A) genes encode monooxygenases-enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A family members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster maps to gene locus 7q22.1 and consists of four genes (CYP3A4, CYP3A5, CYP3A7 and CYP3A43) and two pseudogenes (CYP3A4 is abundant in the endoplasmic reticulum of liver cells and upper intestinal enterocytes. CYP3A4 expression is isducible by glucocorticoids pharmacological agents.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
CYP3A4; CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1
Swiss Prot
P08684
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A4 (NP_059488.2) .
Conjugation
Unconjugated
Applications
WB IF/ICC
Dilution
WB 1:500 - 1:2000 IF/ICC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 57 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CYP3A4 polyclonal antibody detects endogenous levels of CYP3A4 protein.
Applications Notes
Immunofluorescence analysis of HeLa cells using CYP3A4 antibody at dilution of 1:100 (40x lens) .
Host or Source
Rabbit

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MBS2530168-01CYP3A4 Polyclonal Antibody

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