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ACE2 monoclonal antibody

CAT: 0384-MB67195-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB67195-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ACE2 is a carboxypeptidase that catalyses the conversion of angiotensin I to angiotensin 1-9, or of angiotensin II to the vasodilator angiotensin 1-7. ACE2 is a critical component in the renin-angiotensin system (RAS) . ACE2 is predominantly expressed in vascular endothelial cells of the heart and kidney and Leydig and Sertoli cells of the testis. The unique expression pattern of ACE2 determines its essential role in the regulation of cardiovascular and kidney functions, as well as fertility. ACE2 protein is localized mainly in the extracellular space with its carboxy-terminal end attached to the membrane via its transmembrane domain. Active ACE2 enzyme is secreted by cleavage at the amino terminus. Research studies have shown that ACE2 expression is elevated in human failing heart. ACE2 has also been identified as the receptor for SARS and SARS-CoV-2 coronaviruses.
CAS Number
9007-83-4
Structure Composition
Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15
Swiss Prot
Q9BYF1
Reactivity
Human
Immunogen
Recombinant fusion protein of human ACE2. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 100-120 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of ACE2 protein.
Applications Notes
Western blot analysis of ACE2 expression in 293 (A), K562 (B), MCF7 (C), SKBR3 (D), T47D (E), MDAMB453 (F), mouse testis (G) whole cell lysates.
Host or Source
Mouse

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