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CDC25C monoclonal antibody

CAT: 0384-MB66962-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66962-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis . cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint . When phosphorylated at Ser216, cdc25C binds to members of the 14-3-3 family of proteins, sequestering cdc25C in the cytoplasm and thereby preventing premature mitosis . The checkpoint kinases Chk1 and Chk2 phosphorylate cdc25C at Ser216 in response to DNA damage .
CAS Number
9007-83-4
Structure Composition
Mouse IgG2a kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
M-phase inducer phosphatase 3; Dual specificity phosphatase Cdc25C
Swiss Prot
P30307
Reactivity
Human
Immunogen
Recombinant fusion protein of human CDC25C. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Cell Cycle G2 M DNA Damage Signaling Pathway, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway.
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CDC25C protein.
Applications Notes
Western blot analysis of CDC25C expression in HepG2 (A), K562 (B), MCF7 (C), Raji (D) whole cell lysates.
Host or Source
Mouse

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