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CD252 monoclonal antibody

CAT: 0384-MB66937-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66937-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
OX40 is a member of the tumor necrosis factor receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and results in the formation of a TCR-independent signaling complex. One component of this complex, PKC, activates the NF-B pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types.
CAS Number
9007-83-4
Structure Composition
Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.
Product Name Alternative
TXGP1; Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD252
Swiss Prot
P23510
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD252. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/2000)
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CD252 protein.
Applications Notes
Western blot analysis of CD252 expression in HL60 (A) whole cell lysates.
Host or Source
Mouse

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