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C-Jun monoclonal antibody

CAT: 0384-MB66808-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66808-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA) -induced expression of responsive genes through the TPA response element (TRE) . The Jun proteins form homo- and heterodimers which bind the TRE, while Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. An inhibitor of Fos/Jun function, termed IP-1, associates with Fos and Jun and is inactivated upon phosphorylation induced by the cAMPdependent protein kinase A (PKA) .
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
Swiss Prot
P05412
Reactivity
Human, Mouse
Immunogen
KLH-conjugated synthetic peptide of human c-Jun. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Regulation of Apoptosis, ErbB HER Signaling, SAPK JNK Signaling Cascades, T cell receptor signaling
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of c-Jun protein.
Applications Notes
Western blot analysis of c-Jun expression in 293 (A), NIH3T3 (B) whole cell lysates.
Host or Source
Mouse

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