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MITF monoclonal antibody

CAT: 0384-MB66734-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66734-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MITF (microphthalmia-associated transcription factor) is a melanocytic nuclear protein that contains basic helix-loop-helix (HLH) and leucine zipper (LZ) domains. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. MITF can directly associate with DNA as a homodimer and is required for the development and differentiation of melanocytes. Its expression is upregulated by cAMP and cAMP-dependent pathways. MITF activates several different gene promoters by binding to their E-boxes. Tyrosinase, TRP1 and TRP2 are pigment synthesis genes activated by MITF. When MITF is phosphorylated on Ser73 (via the MAPK pathway), it associates with co-activators of the p300/CBP family and enhances transcription. MITF has several isoforms including MITF-M which is specifically expressed in melanocytes. In MITF-deficient mice there is a complete absence of melanocytes.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
BHLHE32; Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; bHLHe32
Swiss Prot
O75030
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human MITF. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000), IHC (1/100 - 1/500)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 59 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of MITF protein.
Applications Notes
Western blot analysis of MITF expression in A431 (A), PC12 (B), NIH3T3 (C) whole cell lysates.
Host or Source
Mouse

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NBP3-11593PEMouse Monoclonal MITF Antibody (MITF/915) [PE]
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NBP3-11593PCPMouse Monoclonal MITF Antibody (MITF/915) [PerCP]
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NBP3-08590HRabbit Monoclonal MITF Antibody (MITF/2987R) [HRP]
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