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STAT5A monoclonal antibody

CAT: 0384-MB66598-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66598-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Stat5 is activated in response to a wide variety of ligands, including IL-2, GM-CSF, growth hormone, and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility. Stat5a and Stat5b are independently regulated and activated in various cell types. For instance, interferon treatment predominantly activates Stat5a in U-937 cells and Stat5b in HeLa cells.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
STAT5; Signal transducer and activator of transcription 5A
Swiss Prot
P42229
Reactivity
Human, Mouse
Immunogen
Purified recombinant human Stat5a protein fragments expressed in E.coli.
Conjugation
Unconjugated
Related Pathways
ErbB HER Signaling, Jak Stat : IL-6 Receptor Signaling
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 90 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of STAT5A protein.
Applications Notes
Western blot analysis of STAT5A expression in NIH3T3 (A), A549 (B), Molt4 (C), K562 (D), Hela (E) whole cell lysates.
Host or Source
Mouse

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